GIANT RETROPERITONEAL LIPOSARCOMA- A RARE CASE REPORT
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Keywords
retroperitoneal liposarcoma, giant abdominal lump, retroperitoneal mass
Abstract
Background: The most prevalent soft tissue sarcoma in the retroperitoneum is liposarcoma. Although retroperitoneal sarcoma (RPS) is a rare disease, any general surgeon may be able to identify and treat it. Retroperitoneal liposarcoma (RPLS) is the most prevalent histological subtype of RPS, accounting for around 30% of all RPS cases. Surgical resection is the conventional treatment for RPLS, and radiotherapy or chemoradiotherapy is often used as a neoadjuvant treatment. Chemotherapy and radiotherapy have been demonstrated to be useful in the treatment of extremity soft tissue sarcoma. However, the positive effects of these therapy for RPS remain debatable. Nonetheless, some studies have found that chemotherapy or chemoradiotherapy had a significant tumour suppressing impact in RPLS patients. Methods: In this paper, we present a rare instance of dedifferentiated retroperitoneal liposarcoma. Conclusion: Dedifferentiated liposarcomas should be treated with radical surgical excision, with multi-visceral resection if necessary. In patients who present with non-specific abdominal symptoms, a high index of suspicion for RPS should be maintained. Surgery is still the gold standard for treating intra-abdominal liposarcomas.
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1. Shibata D, Lewis JJ, Leung DH, Brennan MF. Is there a role for incomplete resection in the management of retroperitoneal liposarcomas?. Journal of the American College of Surgeons. 2001 Oct 1;193(4):373-9. 2. Lewis JJ, Leung D, Woodruff JM, Brennan MF. Retroperitoneal soft-tissue sarcoma: analysis of 500 patients treated and followed at a single institution. Annals of surgery. 1998 Sep;228(3):355. 3. Ardoino I, Miceli R, Berselli M, Mariani L, Biganzoli E, Fiore M, Collini P, Stacchiotti S, Casali PG, Gronchi A. Histology‐specific nomogram for primary retroperitoneal soft tissue sarcoma. Cancer. 2010 May 15;116(10):2429-36. 4. Singer S, Antonescu CR, Riedel E, Brennan MF. Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma. Annals of surgery. 2003 Sep 1;238(3):358-71. 5. Fletcher CD. Pathology and genetics of tumors of soft tissue and bone. World health organization classification of tumors. 2002;4:35-46. 6. Jaques DP, Coit DG, Hajdu SI, Brennan MF. Management of primary and recurrent soft-tissue sarcoma of the retroperitoneum. Annals of Surgery. 1990 Jul;212(1):51. 7. Kilkenny 3rd JW, Bland KI, Copeland 3rd EM. Retroperitoneal sarcoma: the University of Florida experience. Journal of the American College of Surgeons. 1996 Apr 1;182(4):329-39. 8. McGrath PC, Neifeld JP, Lawrence Jr WA, DeMay RM, Kay SA, Horsley 3rd JS, Parker GA. Improved survival following complete excision of retroperitoneal sarcomas. Annals of surgery. 1984 Aug;200(2):200. 9. Mendenhall WM, Zlotecki RA, Hochwald SN, Hemming AW, Grobmyer SR, Cance WG. Retroperitoneal soft tissue sarcoma. Cancer. 2005 Aug 15;104(4):669-75. 10. Jones RL, Fisher C, Al-Muderis O, Judson IR. Differential sensitivity of liposarcoma subtypes to chemotherapy. European journal of cancer. 2005 Dec 1;41(18):2853-60. 11. Raut CP, Pisters PW. Retroperitoneal sarcomas: combined‐modality treatment approaches. Journal of surgical oncology. 2006 Jul 1;94(1):81-7. 12. Khalid M. Educational leadership and choice of postgraduate surgical training. Journal of Musculoskeletal Surgery and Research. 2019 Apr 1;3(2):177. 13. Almond LM, Tirotta F, Tattersall H, Hodson J, Cascella T, Barisella M, Marchianò A, Greco G, Desai A, Ford SJ, Gronchi A. Diagnostic accuracy of percutaneous biopsy in retroperitoneal sarcoma. Journal of British Surgery. 2019 Mar;106(4):395-403. 14. Singer S, Antonescu CR, Riedel E, Brennan MF. Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma. Annals of surgery. 2003 Sep 1;238(3):358-71. 15. Trans-Atlantic RPS Working Group. Management of primary retroperitoneal sarcoma (RPS) in the adult: a consensus approach from the Trans-Atlantic RPS Working Group. Annals of surgical oncology. 2015 Jan;22:256-63. 16. Lewis JJ, Leung D, Woodruff JM, Brennan MF. Retroperitoneal soft-tissue sarcoma: analysis of 500 patients treated and followed at a single institution. Annals of surgery. 1998 Sep;228(3):355. 17. Zeng X, Liu W, Wu X, Gao J, Zhang P, Shuai X, Tao K. Clinicopathological characteristics and experience in the treatment of giant retroperitoneal liposarcoma: a case report and review of the literature. Cancer Biology & Therapy. 2017 Sep 2;18(9):660-5. 18. Guraya SY. The changing landscape of surgical education and training. Journal of Musculoskeletal Surgery and Research. 2018 Jan 1;2(1):1. 19. Khalid M. Educational leadership and choice of postgraduate surgical training. Journal of Musculoskeletal Surgery and Research. 2019 Apr 1;3(2):177. 20. Forgione A, Kislov V, Guraya SY, Kasakevich E, Pugliese R. Safe introduction of laparoscopic colorectal surgery even in remote areas of the world: the value of a comprehensive telementoring training program. Journal of Laparoendoscopic & Advanced Surgical Techniques. 2015 Jan 1;25(1):37-42. 21. Salman Y G, Antonello F, Sampogna G, Raffaelle P. < The> mapping of preferred resources for surgical education: perceptions of surgical trainees at the Advanced International Minimally Invasive Surgery Academy [AIMS], Milan, Italy. 22. Singer S, Corson JM, Demetri GD, Healey EA, Marcus K, Eberlein TJ. Prognostic factors predictive of survival for truncal and retroperitoneal soft-tissue sarcoma. Annals of surgery. 1995 Feb;221(2):185. 23. Lee HS, Yu JI, Lim DH, Kim SJ. Retroperitoneal liposarcoma: the role of adjuvant radiation therapy and the prognostic factors. Radiation oncology journal. 2016 Sep;34(3):216.. 24. Ecker BL, Peters MG, McMillan MT, Sinnamon AJ, Zhang PJ, Fraker DL, Levin WP, Roses RE, Karakousis GC. Preoperative radiotherapy in the management of retroperitoneal liposarcoma. Journal of British Surgery. 2016 Dec;103(13):1839-46. 25. McCallum OJ, Burke II JJ, Childs AJ, Ferro A, Gallup DG. Retroperitoneal liposarcoma weighing over one hundred pounds with review of the literature. Gynecologic oncology. 2006 Dec 1;103(3):1152-4. 26. Gronchi A, De Paoli A, Dani C, Merlo DF, Quagliuolo V, Grignani G, Bertola G, Navarria P, Sangalli C, Buonadonna A, De Sanctis R. Preoperative chemo-radiation therapy for localised retroperitoneal sarcoma: a phase I–II study from the Italian Sarcoma Group. European journal of cancer. 2014 Mar 1;50(4):784-92. 27. Raut CP, Callegaro D, Miceli R, Barretta F, Rutkowski P, Blay JY, Lahat G, Strauss DC, Gonzalez R, Ahuja N, Grignani G. Predicting Survival in Patients Undergoing Resection for Locally Recurrent Retroperitoneal Sarcoma: A Study and Novel Nomogram from TARPSWGRecurrent Retroperitoneal Sarcoma Nomogram. Clinical cancer research. 2019 Apr 15;25(8):2664-71. 28. Neuhaus SJ, Barry P, Clark MA, Hayes AJ, Fisher C, Thomas JM. Surgical management of primary and recurrent retroperitoneal liposarcoma. Journal of British Surgery. 2005 Feb;92(2):246-52.
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GIANT RETROPERITONEAL LIPOSARCOMA- A RARE CASE REPORT. 2022 Dec. 28;93(6): 371-377. Available from: https://mattioli.1885journals.com/article/371.html
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