SYNTHESIS, CHARACTERIZATION AND ANTI-PROLIFERATIVE EVALUATION OF ISOINDOLINE-1,3-DIONE DERIVATIVES
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In the present study, some potential anti-proliferative compounds: isoindoline-1,3-dione derivatives A1-A11 have been synthesized from various Schiff bases (aromatic amines) 1-11. The newly synthesized compounds were optimized by Thin layer chromatography and various physical parameters were as their structural assignments were based on elemental (C, H, N) and Spectral (IR, 1H-NMR, Mass) analysis. Then, these compounds were screened for the anti-proliferative activity against various bacterial and fungal strains. The result of anti-proliferative screening has shown that iso-indoline-1,3-dione derivatives (A1-A11) possessed prominent anti-proliferative profile. The compound A10 and A11 possessed mild against MDA-MB-231 (Human Breast Cancer Cell) and A11 and A1 showed antiproliferative activity against MCF-7 (Human Breast Cancer Cell) as compared to the other synthesized compounds showed most efficient and potent anti-proliferative activity with reference to the standard drug, Adriamycin (Doxorubicin).
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