TCF7L2 RS12255372 (G/T) EMERGENCE AS A PROSPECTIVE GENE FOR TYPE 2 DIABETES MELLITUS PREDISPOSITION
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Keywords
TCF7L2, T2DM, Polymorphism, Genotype
Abstract
Background and aim: There is a chance that Transcription Factor 7 Like 2 (TCF7L2) variants could lead to type 2 diabetes mellitus (T2DM) but the results are debatable. In this study, we sought to ascertain the correlation between the TCF7L2 rs12255372 variation and the likelihood of T2DM in the North Indian cohort. Methods: For this study, 154 patients and 154 healthy controls between 25-75 years were enrolled. Fasting and postprandial blood sugar levels, glycated haemoglobin (HbA1c), a lipid profile, liver function test (LFT) and kidney function test (KFT) were among the biochemical tests carried out. Commercially available kits were used to measure the levels of TCF7L2 in the blood. To genotype samples, PCR-RFLP was utilised. Results: The overall mean of the biochemical profile showed that people with T2DM had considerably higher results than healthy controls (p˂ 0.001). When compared to healthy individuals, T2DM was shown to have significantly reduced levels of circulatory TCF7L2 (p=0.045). The genotypes GG and GT but also GG and TT were positively related with T2DM patients (p=0.0389 and p=0.0305, respectively). The prevalence of the “T” allele of rs12255372 (G/T) polymorphism was substantially greater in cases (30.51%) compared to controls (20.77%). Conclusions: The current investigation verified a considerable linkage between increased susceptibility of T2DM in the North Indian community and the TCF7L2 gene rs12255372 (G/T) polymorphism. It was discovered that the circulatory TCF7L2 levels in T2DM subjects are significantly impacted by the GT genotype of rs12255372. (www.actabiomedica.it)
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