HERBAL APPROACH TO ARTHRITIS MANAGEMENT: INVESTIGATING THE ANTI-ARTHRITIC PROPERTIES AND PHYTOCHEMICAL ANALYSES OF MELIA AZEDARACH LEAF EXTRACT
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Keywords
Arthritis, Melia azedarach, In-vitro analysis,
Abstract
Introduction: Arthritis is the leading cause of disablement, affecting around 350 million people worldwide. Arthritis describes a condition that affects bone joints, joint tissues & connective tissues causing inflammation, pain, stiffness, limited movement and making it difficult to perform daily tasks affecting the quality of life. As of now, a definitive cure for arthritis has not been identified, several therapies are available to control symptoms and elevate the overall standard of life, including medications, physical therapy, lifestyle changes, and surgery etc. Objectives: Herbal treatments have been employed for centuries to manage a number of health disorders, and they continue to be an important form of treatment today due to their natural, safer, easily accessible and eco-friendly aspects. In continue with this herbal approach, we have targeted Melia azedarach (chinaberry) for its antiarthritic effect. Melia azedarach is a deciduous tree in the Meliaceae family, earlier researches shown the anti-inflammatory, antifertility, astringent, antiseptic, diuretic, and deobstruent activity etc. But antiarthritic effect of Melia azedarach has not been studied. Methods: In this research, ethanolic extract of Melia azedarach leaf has been tested for antiarthritic activities using protein denaturation utilizing egg albumin, bovine serum protein denaturation, HRBC membrane stabilization and proteinase inhibitory assay in in-vitro models. The Melia azedarach extract also examined for phytochemical assay which shows the presence Flavonoids, Saponins, Glycosides, Phenols, Tannins, Alkaloids, Terpenes, Anthraquinone, Reducing sugar. Result: The result of the in-vitro analyses showed the significant inhibition in protein denaturation, proteinase and moderate inhibition in HRBC membrane stabilization with potential antiarthritic effect.
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October 15, 2023
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Ayesha Khatun1, Mohammad Akhlaquer Rahman 2, Mohammed Marzouq Awadh Alotaibi 3, Majed Mohammed B Alotaibi 4 , Khalid Abdulaziz A Alhumaid 4, Md Salahuddin Ansari 4, Md. Sarfaraz Alam 1, Aamir Malik1,*
HERBAL APPROACH TO ARTHRITIS MANAGEMENT: INVESTIGATING THE ANTI-ARTHRITIC PROPERTIES AND PHYTOCHEMICAL ANALYSES OF MELIA AZEDARACH LEAF EXTRACT
. 2023 . 13;94(2): 429-454. Available from: https://mattioli.1885journals.com/article/2023/2023-02-429.html
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