BIOMARKERS AND BIOSENSORS FOR HUMAN CANCERS TOWARDS EARLY DETECTION AND PROGNOSIS
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Keywords
Cancers, biomarkers, biosensors, early detection, prognosis.
Abstract
Cancer is a group of diseases characterized by abnormal cell development and propensity to spread. Cancers are currently ranked as a major cause of mortality globally, owing to the various challenges they pose. One such challenge is the widespread lack of early detection, which, in turn, prevents early interventions that are more effective than interventions after disease progression. A variety of biomarkers have been identified for various types of cancers, including proteins, DNA/RNA, protein hormones, autoantibodies, circulating tumor cells, Circulating carcinoma antigens, circulating cell-free tumor nucleic acids, circulating microRNAs, and circulating extracellular vesicles in the peripheral blood. These biomarkers can be utilized to develop biosensors that can aid in early detection when implemented through effective screening strategies in high-risk individuals. Advancements in biomedical engineering have increased the precision and sensitivity of biosensors for detecting and quantifying specific biomarkers. The major benefits of such sensors are the minimal requirement of biological samples, less time taken to obtain results, and their specificity, which together help clinicians choose an appropriate early intervention strategy that can even be individual-specific and precise. Here, we present a comprehensive account of the various biomarkers and biosensors developed across a wide range of biomedical engineering platforms that are relevant for early cancer detection, intervention planning, and prognosis.
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June 10, 2023
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Mugip Rahaman Abdul wahab1, Thirunavukkarasu Palaniyandi1, 2*, Senthil kumar Kaliyamoorthy3, Sandhiya viswanathan1, Gomathy Baskar1, Hemapreethi Surendarn1, S. G. D. Gangadharan4, Saravanan Kumarasamy5.
BIOMARKERS AND BIOSENSORS FOR HUMAN CANCERS TOWARDS EARLY DETECTION AND PROGNOSIS
. 2023 Mar. 13;94(1): 2017-2042 . Available from: https://mattioli.1885journals.com/article/2023/2017.html
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