HYPONATREMIA IN SPONTANEOUS SUBARACHNOID HEMORRHAGE PATIENTS: PREVALENCE AND IMPACT ON DURATION OF HOSPITAL STAY

Main Article Content

Zeeshan Ullah1, Muhammad Fawad Khan2, Asim Ali Shah3, Hina Nawaz4, Ihtisham Ullah5, Imad Majeed 6, Sami Ullah Khan 7, Saad Ali 8

Keywords

#

Abstract

Introduction: This cross-sectional study aimed to investigate the prevalence of hyponatremia and its impact of hyponatremia on the length of hospital stay in subarachnoid hemorrhage patients (SAH) in the local population. Methodology: The study was conducted at the Department of Neurology, Lady Reading Hospital, Peshawar, for 1 year, from 12/2/2022 to 11/2/2023. The sample size was 90, and consecutive sampling was used to select the study participants. The inclusion criteria were patients aged between 20 and 70 years with SAH, while the exclusion criteria were patients with confounding conditions. Results: The study found a high prevalence of hyponatremia (42%) in SAH patients, and it was associated with longer hospital stays 8.2 days (SD=3.5). The difference in mean hospital stay between patients with and without hyponatremia was statistically significant (t=3.2, p0.002). Discussion: These findings emphasize the need for early detection and management of hyponatremia in SAH patients to prevent adverse outcomes and reduce the psychosocial and financial burden on patients and their families. The study highlights the importance of generating local statistics on sodium imbalance in SAH and informing policy recommendations for better and early management of this challenging neurological emergency. Conclusion: In conclusion, this study highlights the high prevalence of hyponatremia in SAH patients and its association with prolonged hospital stay. Early detection and management of hyponatremia in SAH patients should be prioritized to improve outcomes and reduce the burden on patients and their families.

Downloads

References


1. Abello AL, Nunes RH. Subarachnoid Hemorrhage. Critical Findings in Neuroradiology: Springer; 2016. p. 113-9. 2. Dority JS, Oldham JS. Subarachnoid hemorrhage: an update. Anesthesiol Clin. 2016;34(3):577-600. 3. Müller TB, Vik A, Romundstad PR, Sandvei MS. Risk factors for unruptured intracranial aneurysms and subarachnoid hemorrhage in a prospective population-based study. Stroke. 2019;50(10):2952-5. 4. Ridwan S, Zur B, Kurscheid J, Esche J, Kristof R, Klingmüller D, et al. Hyponatremia After Spontaneous Aneurysmal Subarachnoid Hemorrhage—A Prospective Observational Study. World Neurosurg. 2019;129:e538-e44. 5. Hoffman H, Ziechmann R, Gould G, Chin LS. The impact of aneurysm location on incidence and etiology of hyponatremia following subarachnoid hemorrhage. World Neurosurg. 2018;110:e621-e6. 6. Kieninger M, Kerscher C, Bründl E, Bele S, Proescholdt M, Zeman F, et al. Acute hyponatremia after aneurysmal subarachnoid hemorrhage: Frequency, treatment, and outcome. J Clin Neurosci. 2021;88:237-42. 7. Alabbas F, Hadhiah K, Al-Jehani H, Al-Qahtani SY. Hyponatremia as predictor of symptomatic vasospasm in aneurysmal subarachnoid hemorrhage. Interdisciplinary Neurosurgery. 2020;22:100843. 8. Mapa B, Taylor BE, Appelboom G, Bruce EM, Claassen J, Connolly ES. Impact of hyponatremia on morbidity, mortality, and complications after aneurysmal subarachnoid hemorrhage: a systematic review. World Neurosurg. 2016;85:305-14. 9. Escamilla-Ocañas CE, Rao CPV, Bershad E, Damani R. Temporal Relationship between Hyponatremia and Development of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage Patients: A Retrospective Observational Study. J Stroke Cerebrovasc Dis. 2020;29(6):104789. 10. Saramma P, Menon RG, Srivastava A, Sarma PS. Hyponatremia after aneurysmal subarachnoid hemorrhage: Implications and outcomes. J Neurosci Rural Pract. 2013;4(1):24-28. 11. Sherlock M, O’Sullivan E, Agha A, Behan LA, Rawluk D, Brennan P, et al. The incidence and pathophysiology of hyponatraemia after subarachnoid hemorrhage. Clin Endocrinol. 2006;64:250–4. 12. Qureshi AI, Suri MF, Sung GY, Straw RN, Yahia AM, Saad M, et al. Prognostic significance of hypernatremia and hyponatremia among patients with aneurysmal subarachnoid hemorrhage. Neurosurg. 2002;50:749–55. 13. Chandy D, Sy R, Aronow WS, Lee WN, Maguire G, Murali R. Hyponatremia and cerebrovascular spasm in aneurysmal subarachnoid hemorrhage. Neurol India. 2006;54:273–5. 14. Kao L, Al-Lawati Z, Vavao J, Steinberg GK, Katznelson L. Prevalence and clinical demographics of cerebral salt wasting in patients with aneurysmal subarachnoid hemorrhage. Pituitary. 2009;12:347–51. 15. Benvenga S. What is the pathogenesis of hyponatremia after subarachnoid hemorrhage? Nat Clin Pract Endocrinol Metab. 2006;2:608–9. 16. See AP, Wu KC, Lai PM, Gross BA, Du R. Risk factors for hyponatremia in aneurysmal subarachnoid hemorrhage. J Clin Neurosci. 2016 Oct;32:115-8. 17. Marupudi NI, Mittal S. Diagnosis and Management of Hyponatremia in Patients with Aneurysmal Subarachnoid Hemorrhage. J Clin Med. 2015;4(4):756-767.