APPLICATION OF IONOTROPIC GELATION TECHNIQUE IN FORMULATING AND ASSESSING LEVOFLOXACIN HEMIHYDRATE LOADED MICROSPHERES
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Aim: The aim is to formulate and evaluate Levofloxacin hemihydrate loaded microspheres. Methods: Microspheres were prepared by ionotropic gelation method. To achieve the gastro retentive activity in this study by blending polymers. Results: In this work, a mixture of polymers, including Carbopol 934P and HPMC K100M, was used to obtain the gastroretentive property. Levofloxacin hemihydrate-loaded microspheres ranged in drug concentration from 46.2% to 53%. The prepared microspheres have a range in encapsulation efficiency of 62.1% to 82%. Angle of repose micrometric parameters range from 26.14° to 27.99°, bulk density is between 0.27g/ml and 0.31g/ml, tapped density is between 0.33g/ml and 0.37g/ml, compressibility index is between 12.2% and 15.9%, and hausner’s ratio is between 1.12 and 1.17. By combining the polymers of carbopol 934P and HPMC K 100M, drug release was increased.
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1. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984; 1(1): 1311-1315. 2. Amieva MR, El-Omar EM. Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology. 2008; 134(1): 306-323. 3. Scott D, Weeks D, Melchers K, Sachs G. The life and death of Helicobacter pylori. Gut. 1998; 43 Suppl 1(1): S56-S60. 4. O'Rourke J, Bode G. Morphology and ultrastructure (Chapter 6). In: Mobley HLT, Mendz GL, Hazell SL, editors. Helicobacter pylori: physiology and genetics. Washington (DC): ASM Press. 2001 available from: URL: https://www.ncbi.nlm.nih.gov/books/ NBK24. 5. Kaprelyants AS, Gottschal JC, Kell DB. Dormancy in non- sporulating 78 bacteria. FEMS Microbiol Rev. 1993; 10(1): 271-285. 6. Yousif A, Farid IA, Al-Qamish J. Metronidazole resistance of Helicobacter pylori in Bahrain. Bahrain Med Bullet. 1995; 1(1): 17-23. 7. Kanbay M, Kanbay A, Boyacioglu S. Helicobacter pylori infection as a possible risk factor for respiratory system disease: A review of the literature. Respir Med. 2007; 101(1): 203-9. 8. Kao CY, Sheu BS, Wu JJ. Helicobacter pylori infection: An overview of bacterial virulence factors and pathogenesis. Biomed J. 2016; 39(1): 14-23. 9. Safavi M, Sabourian R, Foroumadi A. Treatment of Helicobacter pylori infection: Current and future insights. World J Clin Cases. 2016; 4(1): 5-19. 10. Zhao S, Lv Y, Zhang JB, Wang B, Lv GJ, Ma XJ, et al.,Gastroretentive drug delivery systems for the treatment of Helicobacter pylori. World J Gastroenterol. 2014; 20(1): 9321. 11. B. Venkateswara Reddy. et. al., Formulation and evaluation of efavirenz microspheres, Der Pharmacia Letter. 2015; 7(6):1-9. 12. S. M. Sarode, et.al., Formulation and evaluation of floating microspheres of Glipizide, Journal of Chemical and Pharmaceutical Research. 2011; 3(3): 775-783. 13. Ritu verma., Shubham verma., Sokindra kumar. Microspheres- A Noval Drug Delivery System. Research Chronicle in Health Science.2019; 5(1): 5-14. 14. Emara LH, Abdou AR, El-Ashmawy AA, Mursi NM. Preparation and evaluation of metronidazole sustained release floating tablets. Int. J. Pharm. Sci .2014; 6(1): 199-204. 15. Shastri DH, Dodiya HD, Shelat P, Bhanupriy AK. Formulation development and evaluation of a gastroretentive in situ oral gel of cefuroxime axetil. J. Young Pharm. 2016; 8(1): 324-329. 16. Durgapal S, Mukhopadhyay S, Goswami L. Preparation, characterization and evaluation of floating microparticles of ciprofloxacin. Int J Appl Pharm 2017; 9(1): 1-8. 17. Anjali DN, Vijendar C, Goud AK, Anil KD, Khaja M, Anil A. Preparation and evaluation of floating microspheres of cefdinir in treatment of otitis media and respiratory tract infections. J Pharmacovigilance 2016; 4(1):1-4. 18. Josephine LJJ, Mehul RT, Wilson B, Shanaz B, Bincy R. Formulation and in vitro evaluation of floating microspheres of anti-retro viral drug as a gastro retentive dosage form. Int J Res Pharm Chem 2011; 1(1): 519-27. 19. Purohit KK, Garud N. Formulation and evaluation of floating microspheres of losartan potassium using sodium alginate and HPMC by solvent evaporation method. J Drug Delivery Ther 2019; 9(1): 60-6. 20. Gohel M C, amin A F. Formulation and optimization of controlled release Diclofenac sodium microspheres using factorial design. J Controlled release. 1998; 51(2-3): 115-122. 21. KakkarAP. Characterization of Ibuprofen loaded microcapsules prepared by Ionotropic gelatin. Indian J.pharm sci.1995; 57(2): 56-60 22. Lachman L., Lieberman H.A., Kanig J.L. The Theory and Practice of Industrial Pharmacy, 3rd Edition, Published by Varghese Publishing house, Bombay. 1991; 1(1): 293-303. 23. Bangale GS, Shinde GV, Rajesh KS. Development and evaluation of microballons based extended-release drug delivery system for hypertension therapy. Global J Pharm Sci. 2019; 7(1): 1- 11. 24. Kauslya et al,. Formulation and evaluation of floating microspheres of ciprofloxacin by solvent evaporation method using different polymers. Int J Pharm Pharm Sci. 2021; 13(7): 101-108. 25. U S P 23 / N F 18 Asian Edition 1995 Vol II Pp 1085, Vol III, Pp 1794.
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