DEVELOPMENT AND EVALUATION OF TERBINAFINE HYDROCHLORIDE NANO-GEL FORMULATION FOR THE TOPICAL TREATMENT OF ONYCHOMYCOSIS
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Onychomycosis is a fungal infection of the nails that is of great concern due to the poor quality of the nails. Medicines need to go where they want to get better. In particular, the nail unit has different characteristics from the rest of the body. The aim of the current work is to develop a cosmetic capable of delivering antibiotics to and from the nail plate for the treatment of onychomycosis. This disease presents clinically with varying degrees of nail involvement and there are currently only topical treatments indicated when less than 50% of the nail is involved or supplemented with treatment as needed. The strategy used in this study is to improve drug delivery after topical application. Product development begins with identifying QTPPs to ensure focus on product quality throughout the development process. Based on the perception of quality, variables are analyzed to evaluate their impact on the product. Full and partial factorial DoEs were used to generate important data from the variables to be mapped. This approach has advantages over the limited and risky attempts of the traditional one-at-a-time (OFAT) approach. Some of the new functions used in our research are several drilling machines that have improved nail drilling pre-measurement.
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