CYTOGENETIC MONITORING OF THE SHYMKENT CITY POPULATION IN THE FRAMEWORK OF PERSONALIZED MEDICINE.
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Cytogenetic monitoring was carried out among the population of the city of Shymkent of the Republic of Kazakhstan. As a result of the study, it was revealed low potential for chromosomal abnormalities. This may indicate the location of the city in a favorable area near the Aksu-Zhabagly nature reserve. 10,000 indigenous volunteers were analyzed and a total of 417 abnormal cells were identified. The largest number of chromosomal disorders was found near the former lead plant. It should be noted that the identified chromosomal abnormalities do not exceed the stability of mitotic activity.
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1. Bhardwaj, JK, Mittal, M., Saraf, P., and Kumari, P. (2020). Pesticides Induced Oxidative Stress and Female Infertility: a Review. Toxin Rev. 39(1), 1–13. doi:10.1080/15569543.2018.1474926 2. Cepeda, S., Forero-Castro, M., Cárdenas-Nieto, D., Martínez-Agüero, M., and Rondón-Lagos, M. (2020). Chromosomal Instability in Farmers Exposed to Pesticides: High Prevalence of Clonal and Non-clonal Chromosomal Alterations. Rmhp Vol. 13:97-110. doi:10.2147/RMHP.S230953 3. FAO and WHO (2021). Managing Pesticides in Agriculture and Public Health. A Compendium of FAO and WHO Guidelines and Other Resources. second edition. Rome, Italy: FAO and WHO. [Online]. available:https://www.who.int/publications/i/item/9789240022478(Accessed, 2021). 4. McGowan-Jordan, J., Hastings, RJ, and Moore, S. (2020). ISCN 2020. An International System for Human Cytogenomic Nomenclature. Basel, Switzerland: Karger.PubMed Abstract|Google Scholar 5. Nayebbagher, T., Pashaiefar, H., Yaghmaie, M., Alimoghaddam, K., Jalili, M., Esfandbod, M., et al. (2020). Chromosomal Aberrations in Ascetic Fluid of Metastatic Gastric Cancer Patients: A Clustering Analysis. neo 67(1), 185–192. doi:10.4149/neo_2019_190202N105Cross Ref Full Text|Google Scholar 6. Ozkan, E. and Marcelo, MP (2021). in Genetics, Cytogenetic Testing and Conventional Karyotype (Treasure Island, FL: StatPearls Publishing). [Internet].Google Scholar 7. Granada I, Palomo L, Ruiz-Xiville N, Mallo M, Sole F. Cytogenetics in the genomic era. Best Pract Res Clin Haematol. 2020;33(3):101196. 8. Ribeiro IP, Melo JB, Carreira IM. Cytogenetics and cytogenomics evaluation in cancer. Int J Mol Sci. 2019;20(19):4711. 9. Neveling K, Mantere T, Vermeulen S, et al. Next-generation cytogenetics: comprehensive assessment of 52 hematological malignancy genomes by optical genome mapping. Am J Hum Genet. 2021;108(8):1423-1435. 10. Iourov IY. Cytopostgenomics: What is it and how does it work? Curr Genomics. 2019;20:77–8. 11. Silva M, de Leeuw N, Mann K, Schuring-Blom H, Morgan S, Giardino D, et al. European guidelines for constitutional cytogenomic analysis. Eur J Hum Genet. 2019;27:1–16. 12. Miga, KH, Koren, S., Rhie, A., Vollger, MR, Gershman, A., Bzikadze, A., Brooks, S., Howe, E., Porubsky, D., Logsdon, GA, et al. (2020). Telomere-to-telomere assembly of a complete human X chromosome. Nature585, 79–84. 13. Pollak, RM, Zinsmeister, MC, Murphy, MM, Zwick, ME, Mulle, JG; and Emory 3q29 Project (2020). New phenotypes associated with 3q29 duplication syndrome: Results from the 3q29 registry. Am. J. Med. Genet. A.182, 1152–1166. 14. Zheng, Y., Kong, L., Xu, H., Lu, Y., Zhao, X., Yang, Y., Yu, G., Li, P., Liang, F., Jin, H., and Kong, X. (2020). Rapid prenatal diagnosis of Facioscapulohumeral Muscular Dystrophy 1 by combined Bionano optical mapping and karyomapping. Prenat. Diagn. 40, 317–323.
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