CORRELATION BETWEEN INSTANT WAVE - FREE RATIO GUIDED PERCUTANEOUS CORONARY INTERVENTION IN A SINGLE BORDERLINE LESION AND THE CLINICAL OUTCOME USING CANADIAN CARDIOLOGY SOCIETY GRADING OF ANGINAL PAIN
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Background and aim: The severity of coronary artery stenosis can be determined using the instantaneous wave-free ratio (iFR) index. It is a recent physiological measurement that applies related concepts to fractional flow reserve (FFR) but without a hyperemic agent. This work aimed to use iFR to guide percutaneous coronary intervention (PCI) for single coronary artery disease (CAD) and use the Canadian cardiology society (CCS) grading to evaluate the patient complaint before and after PCI. Methods: This prospective multi-center study was conducted on 40 cases with borderline (50%-70%) single CAD. A comprehensive medical history was taken for each patient, and clinical examinations and laboratory investigations were performed. Pre-operative assessment of patients was conducted using the CCS guidelines. The procedure involved percutaneous coronary intervention (PCI) guided by iFR with stent placement. The post-operative assessment was conducted using the CCS guidelines after 3 months. Results: The mean baseline iFR was 0.85 ± 0.016, while post-PCI, it was 0.93 ± 0.039, with a significant difference (P ˂ 0.001). There was a negative correlation between iFR change with Post PCI CCS (r = -0.416, P = 0.008), while there was a positive correlation between iFR change and CCS grade improvement (r = 0.651, P ˂ 0.001). Conclusions: The clinical outcomes of iFR PCI were quite promising. Therefore, future studies should provide insights into the clinical outcomes of iFR PCI over extended periods.
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