FORMULATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF DOLASETRON FOR NASAL DELIVERY
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The purpose of present study was to develop Dolasetron loaded mucoadhesive microspheres for intranasal administration with the aim to improve therapeutic efficacy, avoid hepatic first pass metabolism and increase residence time. Formulating multiparticulate system with mucoadhesive polymers may provide a significant increase in the nasal residence time. In the present work chitosan mucoadhesive microspheres of Dolasetron were prepared byemulsification cross-linking method, with an aim to overcome the drawbacks of the conventional dosage form and to improve therapeutic efficacy of Dolasetron in treatment of nausea and vomiting. The prepared microspheres were evaluated with respect to the particle size, encapsulation efficiency, production yield, swellingability, in vitro mucoadhesion, in -vitro drug release and stability study. It was found that the particle size, swelling ability and incorporation efficiency of microspheres increases with increasing drug-to-polymer ratio. Among all the formulations F6 (1:3) displayed the best result .On drug release kinetic model study, all the formulations follow Zero order. Stability studies revealed that the microspheres kept at 25 ±20˚C and 60±5% RH showed the maximum stability. On the basis of these results, Dolasetron mucoadhesive chitosan microspheres may be considered as a promising nasal delivery system.
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1. Rani N, Singla RK, Narwal S, Kumar N, Rahman M. Medicinal Plants Used as an Alternative to Treat Gingivitis and Periodontitis. Evidence-Based Complementary and Alternative Medicine. 2022 Sep 6;2022. 2. Narwal S, Saini V, Kaushik V. Evaluation of anti-ulcer activity of esomeprazole magnesium trihydrate film in wistar rats with gastric ulceration induced by Indomethacin. EJPM. 2016;3(10):443-7. 3. Mouez MA, Zaki NM, Mansour S, Geneidi AS. Bioavailability enhancement of verapamil HCl via intranasal chitosan microspheres. European Journal of Pharmaceutical Sciences. 2014 Jan 23;51:59-66. 4. Mali KK, Dhawale SC, Dias RJ, Havaldar VD, Ghorpade VS, Salunkhe NH. Nasal mucoadhesive in-situ gel of granisetron hydrochloride using natural polymers. Journal of applied pharmaceutical science. 2015 Jul 27;5(7):084-93. 5. Narwal S, Saini V, Kaushik V. Evaluation of anti-ulcer activity of esomeprazole magnesium trihydrate film in wistar rats with gastric ulceration induced by Indomethacin. EJPM. 2016;3(10):443-7. 6. Pandey J, Shankar R, Kumar M, Shukla K, Kumari B. Development of nasal mucoadhesive microspheres of granisetron: A potential drug. Drug Research. 2020 Aug;70(08):367. 7. Sriram N, Katakam P. Formulation and evaluation of mucoadhesive microspheres of pioglitazone hydrochloride prepared by ionotropic external gelation technique. Journal of Encapsulation and Adsorption sciences. 2016 Mar 2;6(1):22-34. 8. Natarajan R, Raj GE, Rangapriya M, Rajendran NN. Optimization and evaluation of mucoadhesive microspheres of atenolol. International journal of research in pharmacy and chemistry. 2011;1(3):722-9. 9. Lungare S, Bowen J, Badhan R. Development and evaluation of a novel intranasal spray for the delivery of amantadine. Journal of Pharmaceutical Sciences. 2016 Mar 1;105(3):1209-20. 10. Upadhyay PK, Kumar M, Vishwakarma VK, Yadav MK, Yadav VK, Narwal S, Singh B, Noor G, Chauhan SK, Singh MP. An Overview on Underlying Concepts and Mechanisms of Wound Healing. Annals of the Romanian Society for Cell Biology. 2021 Jun 1;25(6):6714-36. 11. Kashikar V, Dhole S, Kandekar U, Khose P. Study of mucoadhesive microsphere of pirfenidone for nasal drug delivery. Asian Journal of Pharmaceutics (AJP). 2014 Aug 30;8(1). 12. Rathore SD, Thakur RR, Narwal S. Solid dispersion a new horizon in novel drug delivery system. JPR. 2012 Feb;5(2):1007-14. 13. Basarkar GD, Shirsath GN, Patil SB. Development of microspheres containing diclofenac diethylamine as sustained release topical formulation. Bull Pharm Res. 2013;3(1):14-22. 14. Narwal S, Kumar A, Chaudhary M, Budhwar V. Formulation of eutectic mixture of curcumin with salicylic acid for improving its dissolution profile. Research Journal of Pharmacy and Technology. 2021;14(4):1875-9. 15. Yadav A, Jain DK. Formulation development and in vitro characterization of bilayer and floating-bioadhesive tablets of propranolol hydrochloride. Asian Journal of Pharmacy & Life Science. 2011 Jan;1(1):2-12. 16. Thakur RR, Rathore DS, Narwal S. Orally disintegrating preparations: recent advancement in formulation and technology. Journal of Drug Delivery and Therapeutics. 2012 May 14;2(3). 17. Pawar VK, Kansal S, Asthana S, Chourasia MK. Industrial perspective of gastroretentive drug delivery systems: physicochemical, biopharmaceutical, technological and regulatory consideration. Expert opinion on drug delivery. 2012 May 1;9(5):551-65. 18. Rani N, Singla RK, Narwal S, Kumar N, Rahman M. Medicinal Plants Used as an Alternative to Treat Gingivitis and Periodontitis. Evidence-Based Complementary and Alternative Medicine. 2022 Sep 6;2022. 19. Fazil M, Md S, Haque S, Kumar M, Baboota S, kaurSahni J, Ali J. Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting. European Journal of Pharmaceutical Sciences. 2012 Aug 30;47(1):6-15. 20. Wang QS, Wang GF, Zhou J, Gao LN, Cui YL. Colon targeted oral drug delivery system based on alginate-chitosan microspheres loaded with icariin in the treatment of ulcerative colitis. International journal of pharmaceutics. 2016 Dec 30;515(1-2):176-85. 21. Rani N, Singla RK, Redhu R, Narwal S, Sonia, Bhatt A. A Review on Green Synthesis of Silver Nanoparticles and its Role against Cancer. Curr Top Med Chem. 2022;22(18):1460-1471. doi: 10.2174/1568026622666220601165005. PMID: 35652404. 22. Alok Bhatt, Arun Kumar, Sonia Narwal. Phytochemical Profile of Melissa parviflora Benth. Neuro Quantology. 2022; 20(9): 2426-2428.
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