@article{Soliman_Prabhakaran Nair_Al Masalamani_De Sanctis_Abu Khattab_Alsaud_Sasi_Ali_Ola A._Iqbal_Nashwan_Fahad_El Madhoun_Yassin_2020, title={Prevalence, clinical manifestations, and biochemical data of type 2 diabetes mellitus versus nondiabetic symptomatic patients with COVID-19: A comparative study}, volume={91}, url={https://mattioli1885journals.com/index.php/actabiomedica/article/view/10214}, DOI={10.23750/abm.v91i3.10214}, abstractNote={<p class="p1"><em>Background:</em> There is a scarcity of data regarding the effect of Type 2 diabetes mellitus (T2DM) and associated comorbidities on the clinical presentation and outcome of symptomatic patients with -COVID-19 infection in comparison with non-diabetic patients. <em>Aim of the study:</em> We described and compared the clinical presentation and radiological and hematological data of a cohort of symptomatic COVID19 positive T2DM diabetic patients (n = 59) versus another cohort of non-diabetic symptomatic COVID19 positive patients <br>(n =244) diagnosed at the same time from January 2020 to May 2020. Associated comorbidities were -assessed, and the Charlson Comorbidity Index was calculated. The outcomes including duration of hospitalization, duration of Intensive Care Unit (ICU) stay, duration of mechanical ventilation, and duration of O2 -supplementation were assessed. <em>Results:</em> Prevalence of T2DM in symptomatic COVID19 positive patients was 59/303 (=19.5%).<span class="Apple-converted-space">  </span>Diabetic patients had higher prevalence of hypertension, chronic kidney disease (CKD) and cardiac dysfunction [coronary heart disease (CHD)], and congestive heart failure (CHF). Charlson Comorbidity score was significantly higher in the T2DM patients (2.4± 1.6) versus the non-diabetic -patients (0.28 ± 0.8; p: < 0.001). Clinically and radiologically, T2DM patients had significantly higher percentage of pneumonia, severe pneumonia and ARDS versus the non-diabetic patients. Hematologically, diabetic patients had significantly higher C-reactive protein (CRP), higher absolute neutrophilic count (ANC) and lower counts of lymphocytes and eosinophils compared to non-diabetic patients. They had significantly higher systolic and diastolic blood pressures, longer duration of hospitalization, ICU stay, mechanical ventilation and oxygen therapy. CRP was correlated significantly with the duration of stay in the ICU and the duration for oxygen supplementation (r = 0.37 and 0.42 respectively; p: <0.01). <em>Conclusions:</em> T2DM patients showed higher inflammatory response to COVID 19 with higher absolute neutrophilic count (ANC) and CRP with lower lymphocytic and eosinophilic counts. Diabetic patients had more comorbidities and more aggressive course of the disease with higher rate of ICU admission and longer need for hospitalization and oxygen use. </p>}, number={3}, journal={Acta Biomedica Atenei Parmensis}, author={Soliman, Ashraf T and Prabhakaran Nair, Arun and Al Masalamani , Muna S. and De Sanctis, Vincenzo and Abu Khattab , Mohamad A. and Alsaud, Arwa E. and Sasi, Sreethish and Ali, Elrazi A. and Ola A., Hassan and Iqbal, Fatima M. and Nashwan, Abdulqadir J. and Fahad, Jesin and El Madhoun , Ihab and Yassin, Mohamed A.}, year={2020}, month={Sep.}, pages={e2020010} }