@article{Pesciallo_Garabano_Rodriguez_Viale_Tillet_Del Sel_2022, title={Total Knee Replacement in Alkaptonuric Ochronosis : Two Case Reports and Literature Review }, volume={93}, url={https://mattioli1885journals.com/index.php/actabiomedica/article/view/10439}, DOI={10.23750/abm.v92iS1.10439}, abstractNote={<p><strong>Background and objective:</strong> Alkaptonuria is a rare disease characterized by the accumulation of homogentisic acid (HGA). Over time, these patients may develop disabling ochronotic arthropathy. We present 2 cases of patients with end-stage arthropathy treated with total knee arthroplasty (TKA).</p>
<p><strong>Methods:</strong>  Both patients complained of disabling knee pain and reported limited walking distance (200-300 m). One had a history of osteotomy for medial knee arthtritis and ignored his underlying condition. The other presented with valgus gonoarthrosis and diagnosis of alkaptonuria.</p>
<p><strong>Results:</strong> Intraoperatively, the characteristic dark-blue color in the joint was observed. Both patients evolved favorably after TKA with excellent results according to the Knee Society Scores (KSS) at three years of follow-up.</p>
<p><strong>Conclusion: </strong>We believe TKA is the right treatment for patients with end-stage disease because it offers considerable relief from pain and allows patients to recover function.</p>}, number={S1}, journal={Acta Biomedica Atenei Parmensis}, author={Pesciallo, Cesar and Garabano, German and Rodriguez, Joaquin and Viale, German and Tillet, Fernando and Del Sel, Hernan}, year={2022}, month={Jun.}, pages={e2022108} }