@article{Crafa_Di Mario_Grillo_Landi_Franceschi_Rodriguez-Castro_Tursi_Brandimarte_Franzoni_2022, title={Recovery of gastric function in patients affected by chronic atrophic gastritis using l-cysteine (Acetium®): one year survey in comparison with a control group.: L-cysteine and Chronic Atrophic Gastritis}, volume={93}, url={https://mattioli1885journals.com/index.php/actabiomedica/article/view/12812}, DOI={10.23750/abm.v93i3.12812}, abstractNote={<p><em>Background and aim: </em>Chronic Atrophic Gastritis (CAG) is a precancerous condition for gastric cancer (GC) as single risk factor, being a consequence of a previous Helicobacter pylori (Hp) infection or based on autoimmune mechanisms. Achlorhydria plays an important role towards the formation of a class I carcinogen, acetaldehyde, after food intake. L-cysteine has been claimed to be able to bind in a covalent way acetaldehyde when administered at means.</p> <p><em>Methods</em>: In this study we enrolled two CAG groups of patients, one treated whit 300 mg/daily of L-cysteine for one year, the other one untreated.</p> <p>We assessed gastric function lasting the one year follow-up by using non invasive surrogates, i.e. Pepsinogen I (PGI) and gastrin 17 (G17).</p> <p><em>Results: </em>In the group of 77 CAG on therapy we found a statistically significative increase in PGI values and a decrease in G17 levels, in comparison with unchanged values in control group.</p> <p><em>Conclusions</em>: L-cysteine seems able to provide a recovery in gastric function when administered in CAG patients and could be proposed as a possible therapy in such patients.</p>}, number={3}, journal={Acta Biomedica Atenei Parmensis}, author={Crafa, Pellegrino and Di Mario, Francesco and Grillo, Simone and Landi, Stefano and Franceschi, Marilisa and Rodriguez-Castro, Kryssia and Tursi, Antonio and Brandimarte, Giovanni and Franzoni, Lorella}, year={2022}, month={Jul.}, pages={e2022184} }