@article{Mancini_Alboni_Mattei_Rioli_Sena_Marchi_Sacchetti_Boarino_Roncucci_Galeazzi_Ferrari_2020, title={Preliminary results of a multidisciplinary Italian study adopting a Psycho-Neuro-Endocrine-Immunological (PNEI) approach to the study of colorectal adenomas}, volume={92}, url={https://mattioli1885journals.com/index.php/actabiomedica/article/view/10197}, DOI={10.23750/abm.v92i1.10197}, abstractNote={<p><strong>Background and aim of the work </strong>Colorectal mucosal precancerous lesions, metabolic syndrome (MetS) and psychiatric disorders may share a common low-grade local and systemic inflammation. Aim is to report on preliminary data concerning a research adopting a psycho-neuro-endocrine-immune (PNEI) approach to study outpatients undergoing colonoscopy. <strong>Methods </strong>A sample of patients undergoing colonoscopy was cross-sectionally investigated. Data on colorectal adenomas, MetS, early atherosclerosis, anxious-depressive symptoms, personality traits, and inflammatory markers were statistically analyzed. <strong>Results </strong>Sixty-two patients were recruited (female 50%, mean age: 60.8±9.4 years). The prevalence of adenomas and MetS was respectively of 45.2% and 41.9%. Anxiety and depressive symptoms were detected in 16 (32.7%) and 9 (18.4%) subjects, respectively. The presence of adenomas positively correlated with male sex (p=0.01), age (p<0.01), IL-6 (p=0.03), hsCRP (p=0.04), and MetS (p=0.03); it was also associated with hsCRP concentration (aOR=3.81, p=0.03). <strong>Conclusions</strong> Proinflammatory atherogenic status, psychological traits, increased mucosal inflammation, and metabolic parameters may share a common a pathogenic mechanism, worth studying.</p>}, number={1}, journal={Acta Biomedica Atenei Parmensis}, author={Mancini, Stefano and Alboni, Silvia and Mattei, Giorgio and Rioli, Giulia and Sena, Paola and Marchi, Mattia and Sacchetti, Andrea and Boarino, Valentina and Roncucci, Luca and Galeazzi, Gian Maria and Ferrari, Silvia}, year={2020}, month={Sep.}, pages={e2021014} }