@article{Negro_Paolucci_Russo_Di Stasi_Guerriero_Arrigoni_Bruno_Pagnini_Angileri_Palumbo_Masciocchi_Puoti_Tortora_Caranci_2020, title={Predictive factors of volumetric reduction in lumbar disc herniation treated by O2-O3 chemiodiscolysis}, volume={91}, url={https://mattioli1885journals.com/index.php/actabiomedica/article/view/9975}, DOI={10.23750/abm.v91i8-S.9975}, abstractNote={<p class="p1"><span class="s1"><em>Purpose: </em>Aim of this study is to assess the effectiveness of O<sub>2</sub>-O<sub>3 </sub>percutaneous chemiodiscolysis by evaluating volumetric changes in lumbar disc herniation on magnetic resonance imaging, in order to identify possible pre-treatment factors affecting such changes <em>Methods: </em>Between January 2014 and December 2017, a total of 87 patients with low back pain and 103 lumbar disc herniations with MRI confirmation were considered for O<sub>2</sub>-O<sub>3 </sub>chemiodiscolysis. The volume of each herniated disc was determined before and after the treatment. <em>Results:</em><span class="Apple-converted-space">  </span>Multiple linear regression analysis showed a strong correlation between post-treatment LDH volume percent change and both pre-treatment LDH volume and pre-treatment EQ-VAS (<em>p</em><0.05), while age showed only a weak positive correlation with post-treatment LDH volume percent change (<em>p</em><0.1). No association was found for other factors, such as sex and herniation disc level. <em>Conclusions: </em>In conclusion, age, baseline LDH volume and self-assessed disease severity score could represent three easy accessible outcome predictive parameters to consider when intradiscal O<sub>2</sub>-O<sub>3</sub> chemiodiscolysis is envisaged. Better results after intradiscal O<sub>2</sub>-O<sub>3</sub> chemiodiscolysis were obtained in older patients with higher pre-treatment LDH volume and low-moderate pre-treatment EQ-VAS. </span></p>}, number={8-S}, journal={Acta Biomedica Atenei Parmensis}, author={Negro, Alberto and Paolucci, Aldo and Russo, Camilla and Di Stasi, Martina and Guerriero, Pasquale and Arrigoni, Francesco and Bruno, Federico and Pagnini, Francesco and Angileri, Salvatore Alessio and Palumbo, Pierpaolo and Masciocchi, Carlo and Puoti, Gianfranco and Tortora, Fabio and Caranci, Ferdinando}, year={2020}, month={Jul.}, pages={89–97} }