@article{Kelten Talu_Hacihasanoglu_Leblebici_Nazli_Arslan_Can Trabulus_2021, title={Invasive Breast Carcinoma with Abundant Collagenous Stroma Shows Lower Level of CD68-Positive Tumor Associated Macrophages than Those of Invasive Carcinoma without Abundant Collagenous Stroma }, volume={92}, url={https://mattioli1885journals.com/index.php/actabiomedica/article/view/10954}, DOI={10.23750/abm.v92i5.10954}, abstractNote={<p><strong>Background and aim of the work: </strong>The significance of association between cancer and its stromal microenvironment has been recognized. We aimed to investigate the immunohistochemical staining features of D2-40 (podoplanin), SMA (smooth muscle actin) and CD68 (pan-macrophage marker) in patients with early stage invasive breast cancer with/out peritumoral PASH-like stroma.</p> <p><strong>Methods</strong>: The H&E sections of core needle biopsy specimens of invasive breast carcinomas diagnosed during one-year time period were reviewed in terms of the presence of accompanying PASH-like stroma retrospectively. Cases with similar pattern of growth in their surgical excision materials were included. Eight cases were grouped as ‘Invasive tumor with PASH-like stroma’ and 21 cases as ‘Invasive tumor without PASH-like stroma’, consecutively. The results of immunohistochemical staining for D2-40, SMA and CD68 were noted semiquantitatively as ‘negative’,’weak’, moderate’ or ‘strong’.</p> <p><strong>Results</strong>: CD68 was found significantly lower in invasive tumor with peritumoral PASH-like stroma than those of tumor without PASH-like stroma. No significant differences were found for SMA and D2-40 between two groups. </p> <p><strong>Conclusions</strong>: Tumor-associated macrophages (CD68 positive) in tumor stroma have been demonstrated in association with tumor behavior in several studies. The presence of peritumoral PASH-like stroma, which is poorly staining for CD68, might be a morphological clue for the behavior of tumor. </p>}, number={5}, journal={Acta Biomedica Atenei Parmensis}, author={Kelten Talu, Canan and Hacihasanoglu, Ezgi and Leblebici, Cem and Nazli, Mehmet Ali and Arslan, Esra and Can Trabulus, Didem}, year={2021}, month={Nov.}, pages={e2021254} }