@article{Vitali_Ometti_Pironti_Salvato_Sandrucci_Leone_Salini_2022, title={Clinical and functional evaluation of bone marrow aspirate concentrate vs autologous conditioned serum in the treatment of knee osteoarthritis}, volume={93}, url={https://mattioli1885journals.com/index.php/actabiomedica/article/view/12845}, DOI={10.23750/abm.v93i5.12845}, abstractNote={<p><strong><em>Background and aim</em></strong><em>:</em> The aim of this study was to compare the efficacy of a single Bone Marrow Aspirate Concentrate (BMAC) with a cycle of 4 Autologous Conditioned Serum (ACS) injections in the treatment of early-stage knee osteoarthritis (OA).</p> <p><strong><em>Methods</em></strong><em>:</em> Two groups of 12 patients with degenerative knee OA were treated with a single BMAC injection and with a cycle of 4 ACS injections respectively. Follow-up was set at baseline (t0), one-month (t1) and six-months (t2) evaluating VAS for pain, WOMAC index and range of motion (ROM).</p> <p><strong><em>Results</em></strong><em>:</em> We reported a significant improvement in WOMAC after BMAC injection both at t1 (p= 0,001) as well as t2 (p< 0,001), plus a reduction of VAS values in BMAC group at six months follow-up (p = 0,024). In contrast, no significant differences in ROM between the two groups were observed.</p> <p><strong><em>Conclusions</em></strong><em>:</em> Both the approaches are safe and effective in the treatment of knee OA, with a major efficacy of BMAC.</p>}, number={5}, journal={Acta Biomedica Atenei Parmensis}, author={Vitali, Matteo and Ometti, Marco and Pironti, Pierluigi and Salvato, Damiano and Sandrucci, Alice and Leone , Orlando and Salini, Vincenzo}, year={2022}, month={Oct.}, pages={e2022222} }