@article{Al Senaidi_Maveda_Joshi_Nazir_Elshinawy_AL Zadjali_Al Rawas_Elghamry_Wali_Khater_2022, title={Cardio-protective effect of regular transfusion in children with non-transfusion dependent thalassemia (NTDT): A cohort study }, volume={93}, url={https://mattioli1885journals.com/index.php/actabiomedica/article/view/10736}, DOI={10.23750/abm.v93i2.10736}, abstractNote={<p><strong><em>Background and aim of the work:</em></strong></p> <p> Cardiac complications occur in patients with non-transfusion dependent thalassemia (NTDT). The study aimed to evaluate transfusion effect on systolic and diastolic cardiac function in young NTDT patients.<strong>  </strong></p> <p><strong><em>Methods:</em></strong><strong>  </strong></p> <p>Study design: Cohort study.</p> <p>Seventeen regularly-transfused patients with NTDT (12.5±5.3 years; group 1) and 15 none/minimally transfused patients (13.2±4.8 years; group 2) were followed up for 5 years and compared as regards their clinical parameters, echocardiographic and Tissue-Doppler-Imaging.</p> <p><strong><em>Results:</em></strong> Group 2 patients had significantly higher peak late-diastolic velocity of the left-ventricular-inflow Doppler (Am). Mitral-valve A-wave duration/pulmonary-veins, A-wave duration-ratio and pulmonary-vein S/D velocities-ratio were larger in group 2 as well (p = <u><</u> 0.01). The diameters of right and left outflow-tract were larger with a higher cardiac-index in patients of group 2. Systolic-function was similar in the 2 studied groups.</p> <p><strong><em>Conclusion:</em></strong></p> <p>Diastolic function assessment revealed indicators of an abnormal relaxation of left-ventricle in non-transfused patients, which suggests a diastolic dysfunction. An increase in the diameter of the outflow-tract is likely attributed to high cardiac-output status in non-transfused NTDT patients as they have a higher cardiac index. Early start of regular transfusion for NTDT patients might prevent serious long-term cardiac complications.</p>}, number={2}, journal={Acta Biomedica Atenei Parmensis}, author={Al Senaidi, Khalfan and Maveda, Surekha and Joshi, Niranjan and Nazir , Hanan and Elshinawy, Mohamed and AL Zadjali , Shoaib and Al Rawas , Abdulhakim and Elghamry , Islam and Wali, Yasser and Khater, Doaa}, year={2022}, month={May}, pages={e2022022} }