@article{Giansante_Stivanello_Perlangeli_Ferretti_Marzaroli_Musti_Pizzi_Resi_Saraceni_Pandolfi_2021, title={COVID-19 vaccine effectiveness among the staff of the Bologna Health Trust, Italy, December 2020-April 2021}, volume={92}, url={https://mattioli1885journals.com/index.php/actabiomedica/article/view/11896}, DOI={10.23750/abm.v92i4.11896}, abstractNote={<p><em>Background and aim:</em></p> <p>Randomized controlled trials have shown that mRNA vaccines are highly effective in preventing SARS-CoV2 infection. We conducted a study to assess the real-world effectiveness of mRNA vaccines (Pfizer-BioNTech or Moderna) in preventing all and symptomatic SARS-CoV2 infections and COVID-19 related hospitalizations in the staff of the Bologna Health Trust (HT), Italy</p> <p><em>Methods:</em></p> <p>We followed up retrospectively 9839 staff of the Bologna HT from December 27, 2020 to April 3, 2020 and calculated the effectiveness in partially and fully vaccinated subjects by applying a multivariable Cox proportional hazard model.</p> <p><em>Results:</em></p> <p>Vaccine effectiveness in preventing SARS-CoV2 infections is 85.5% (95%CI: 75.9-91.3) in the partially vaccinated and 84.8% (95%CI: 73.2-91.4) in the fully vaccinated. In preventing symptomatic infection effectiveness is 81.7% (95%CI: 62.7-91.0) in the partially and 87.1% (95%CI: 69.3-94.6) in the fully vaccinated. There were no COVID-19-related hospitalizations in the partially or fully vaccinated vs 15 hospitalization in the unvaccinated cohort.</p> <p><em>Conclusions:</em></p> <p>Our results confirm the effectiveness of mRNA vaccines in a real-world setting in Northern Italy.</p> <p> </p>}, number={4}, journal={Acta Biomedica Atenei Parmensis}, author={Giansante, Chiara and Stivanello, Elisa and Perlangeli, Vincenza and Ferretti, Filippo and Marzaroli, Paolo and Musti, Muriel Assunta and Pizzi, Lorenzo and Resi, Davide and Saraceni, Simona and Pandolfi, Paolo}, year={2021}, month={Sep.}, pages={e2021270} }