@article{Loizzi_Cicinelli_Del Vecchio_Arezzo_Deromemaj_Kardhashi_Paradiso_Legge_Natalicchio_Resta_Resta_Loconte_Cormio_2022, title={A prospective multicentric study of risk-reducing salpingo-oophorectomy in BRCA mutation patients: Risk-reducing salpingo-oophorectomy in BRCA mutations}, volume={93}, url={https://mattioli1885journals.com/index.php/actabiomedica/article/view/11695}, DOI={10.23750/abm.v93i4.11695}, abstractNote={<p><em>Background and aim of the work</em>: BRCA1/2 are tumour-suppressor genes involved in DNA homologous recombination and ovarian cancer development.  The study evaluated the risk of tumor cancer in women presenting the BRCA mutations.</p> <p><em>Methods:</em> Risk-reducing surgery (RRS) was performed in 100 patients carrying BRCA1 (aged between 30-73 years, median age was 51 years) and BRCA 2 mutation (aged between 36-70 years, median age was 53 years). Fifty-eight patients had previous history of breast cancer.</p> <p><em>Results</em>: Between the 100 patients, 82 women underwent risk-reducing salpingo-oophorectomy (RRSO) through a laparoscopic minimally invasive approach, 7 (7 %) underwent laparoscopic RRSO and contextual hysterectomy, 1 woman (1 %) underwent RRSO through a laparotomic approach and 10 women (10 %) laparotomic RRSO and hysterectomy. During 5 (5 %) laparoscopic RRSO, prophylactic bilateral mastectomy was also performed. Early and late complication occurred in 3 patients (3 %). Two patients (2 %) were found to have occult Serous Tubal Intraepithelial Carcinoma (STIC) and three patients (3 %) occult cancer.</p> <p><em>Conclusions</em>: RRSO is safe and feasible in BRCA mutation carriers. The procedure is effective for genetic prevention of ovarian cancer.</p>}, number={4}, journal={Acta Biomedica Atenei Parmensis}, author={Loizzi, Vera and Cicinelli, Ettore and Del Vecchio, Vittoria and Arezzo, Francesca and Deromemaj, Xheni and Kardhashi, Anila and Paradiso, Angelo and Legge, Francesco and Natalicchio, Maria Iole and Resta, Leonardo and Resta, Nicoletta and Loconte, Daria Carmela and Cormio, Gennaro}, year={2022}, month={Aug.}, pages={e2022051} }