Herpes Simplex Virus 1 encephalitis with normal cerebrospinal fluid after brain radiotherapy in a patient with glioblastoma. A case report and review of literature

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Carlotta Mutti
Neurology Department, Parma Hospital

Erica Curti
U.O. di Neurologia, Dipartimento di Medicina e Chirurgia, Università di Parma

Rosario Ciliento
U.O. di Neurologia, Dipartimento di Medicina e Chirurgia, Università di Parma

Andrea Melpignano
U.O. di Neurologia, Dipartimento di Medicina e Chirurgia, Università di Parma

Irene Florindo
U.O. di Neurologia, Dipartimento di Emergenza-Urgenza, Medicina Generale e Specia-listica, Azienda Ospedaliero-Universitaria di Parma;

Lucia Zinno
U.O. di Neurologia, Dipartimento di Emergenza-Urgenza, Medicina Generale e Specia-listica, Azienda Ospedaliero-Universitaria di Parma;

Enrico Sasso
U.O. di Neurologia, Dipartimento di Medicina e Chirurgia, Università di Parma; b U.O. di Neurologia, Dipartimento di Emergenza-Urgenza, Medicina Generale e Specialistica, Azienda Ospedaliero-Universitaria di Parma;

Liborio Parrino
U.O. di Neurologia, Dipartimento di Medicina e Chirurgia, Università di Parma; b U.O. di Neurologia, Dipartimento di Emergenza-Urgenza, Medicina Generale e Specialistica, Azienda Ospedaliero-Universitaria di Parma;

Giovanni Pavesi
a U.O. di Neurologia, Dipartimento di Medicina e Chirurgia, Università di Parma; b U.O. di Neurologia, Dipartimento di Emergenza-Urgenza, Medicina Generale e Specia-listica, Azienda Ospedaliero-Universitaria di Parma;

Anna Elisabetta Vaudano
Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia;

Keywords

Herpes Simplex Virus 1 (HSV1), Encephalitis, Glioblastoma, Radiotherapy

Abstract

Herpes simplex virus encephalitis (HSE) is the most common cause of letal encephalitis and its prevalence appears higher among oncologic patients who undergo brain radiotherapy (RT). We describe a case of 76-year-old woman with glioblastoma multiforme (GBM) who developed HSE shortly after brain RT. Cerebrospinal fluid analysis (CSF) was normal and the diagnosis was driven by brain MRI and EEG. Prompt introduction of antiviral therapy improved the clinical picture. We highlight the importance of EEG and brain MRI for the diagnosis and suggest the possibility of antiviral profilaxys in oncologic patients who undergo brain RT.

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Published
May 23, 2019
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How to Cite

1.
Mutti C, Curti E, Ciliento R, Melpignano A, Florindo I, Zinno L, Sasso E, Parrino L, Pavesi G, Vaudano AE. Herpes Simplex Virus 1 encephalitis with normal cerebrospinal fluid after brain radiotherapy in a patient with glioblastoma. A case report and review of literature. Acta Biomed [Internet]. 2019 May 23 [cited 2023 Feb. 27];90(2):327-30. Available from: 8218
Issue
Vol. 90 No. 2 (2019)
Section
CASE REPORTS

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