THE ROLE OF LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-1 (LRP1) GENE IN OVARIAN CANCER.
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Keywords
Ovarian cancer, Migration, LRP1, Proliferation, Gene polymorphism, Tumor, Invasion, Apoptosis, Signaling pathway, Gene expression
Abstract
Low-density lipoprotein receptor-related protein 1 (LRP1, also known as CD91), is a multifunctional endocytic and cell signaling receptor that is extensively expressed on a range of cell types, including as neurons, fibroblasts, hepatocytes, muscle cells, astrocytes, and tumour cells. Numerous mechanisms that promote carcinogenesis and tumour growth depend significantly on LRP1. For instance, by controlling the expression and activities of matrix metalloproteinase (MMP), LRP1 not only facilitates the migration and invasion of tumour cells but also prevents cell death via controlling the insulin receptor. Extracellular matrix proteins, growth factors, and proteases are among the ligands for which LRP1 functions as a co-receptor. LRP1 has the ability to trigger or alter signaling pathways linked to cell migration, survival, and proliferation through its interactions with various ligands. In malignancies, including ovarian cancer, the PI3K/Akt and MAPK/ERK pathways are frequently unregulated. LRP1 can control the activity of these pathways. According to several studies, the LRP1 protein is essential for the growth, progression, and metastatic spread of ovarian cancer. Research has revealed that elevated expression of LRP1 stimulates the invasion of ovarian cancer cells, whereas inhibiting LRP1 invalidation stops the motility of these cancer cells. This review concentrate on LRP1 gene capacity to control the ovarian cancer migratory characteristics. The proliferation, invasion, and migration of OC tumor cells were decreased by LRP1 knockdown, indicating that LRP1 expression might be a potential target for the therapy of OC tumors.
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