ASSOCIATION OF METABOLIC SYNDROME WITH THE DEVELOPMENT OF GALLSTONE DISEASE – A PROSPECTIVE STUDY

Abstract

Aim: To study the correlation between individual components metabolic syndrome and gall stone disease and to study the rate of gallstone associated complications such as cholecystitis, gallstone pancreatitis, and post cholecystectomy complications in patients with metabolic syndrome. Materials and Methods: A total of 120 patients visiting the medicine and general surgery OPD fulfilling the inclusion and exclusion criteria and willing to participate were included in the study. Patient were then subjected to a complete workup including Laboratory and Radiological investigations. After completion of data collection, data analysis was achieved using SPSS version 16 software, and the correlations sought after were achieved using the chi-square test of significance. Results: According to our study findings, among the 120 patients who visited the surgical outpatient department for gallstone disease, 73 were diagnosed with metabolic syndrome, while the remaining patients exhibited derangement in one or two components. Based on our study, metabolic syndrome was associated with a more than two-fold risk of gallstone disease. More the components of metabolic syndrome, higher the prevalence of gall stone disease. Furthermore, our study provides strong evidence that each component may contribute to different degrees of incidental cholelithiasis. Of the 5 components of metabolic syndrome, absolute predictors and the risk factors for gallstone disease and its complications, were Obesity(65.75%), Diabetes Mellitus(60.27%) and hypertriglyceredemia(50.68%). Therefore, the management of metabolic components, especially Obesity, hypertriglyceredemia and diabetes mellitus, may effectively reduce the risk of gallstone formation. Patients who had both metabolic syndrome and gallstone disease experienced few preoperative complications, such as cholecystitis and gallstone-induced pancreatitis, but these occurrences did not show statistical significance. In our study, there were very few postoperative complications noted, including wound gape and seroma formation Categories: Internal Medicine, General Surgery