FORMULATION DEVELOPMENT AND INVITRO EVALUATION OF A GEL CONTAINING SCHLEICHERA OLEOSA LEAF EXTRACT
Main Article Content
Keywords
Schleichera Oleosa, Gel formulation, Leaf extract, Anti-inflammatory, Antimicrobial
Abstract
The study focusses on the production and structure of a gel using an extract from the leaves of Schleichera Oleosa, which is well-known for its potent medicinal properties. The goal was to create a topical gel that harnesses the medical benefits of the extract, namely its anti-inflammatory, antioxidant, and antibacterial capabilities. The formulation process included meticulous selection of suitable gelling agents, precise adjustment of the concentration of Schleichera Oleosa leaf extract, and ensuring the stability and consistency of the gel. The optimal formulation was identified by assessing several physicochemical properties, including pH, viscosity, and spreadability. Furthermore, compatibility trials were conducted to confirm the durability of the extract inside the gel matrix. The biological efficacy of the produced gel was evaluated using In Vitro analysis. The effectiveness of the gel in treating infections was assessed by performing antimicrobial tests against prevalent skin pathogens. The effectiveness of the gel in reducing inflammation was confirmed by assessing its anti-inflammatory activity via recognised methods. The gel's antioxidant capacity was also evaluated to confirm its ability to neutralise free radicals. The research demonstrated that the gel derived from the extract of Schleichera Oleosa leaves had potent antibacterial, anti-inflammatory, and antioxidant activities. This implies that it might be a beneficial topical treatment for several skin ailments. Further investigation is advised to examine the efficacy of the gel when applied to a live creature and its potential applications in the area of dermatology.
Downloads
References
1. Alshehri, S., Bukhari, S I., Imam, S S., Hussain, A., Alghaith, A F., Altamimi, M A., AlAbdulkarim, A S., & Almurshedi, A S. (2023, June 15). Formulation of Piperine-Loaded Nanoemulsion: In Vitro Characterization, Ex Vivo Evaluation, and Cell Viability Assessment. American Chemical Society, 8(25), 22406-22413. https://doi.org/10.1021/acsomega.2c08187 2. Alternative Cutaneous Substitutes Based on Poly(l-co-d,l-lactic acid-co-trimethylene carbonate) with Schinus terebinthifolius Raddi Extract Designed for Skin Healing. (2023, October 26). https://pubs.acs.org/doi/pdf/10.1021/acsomega.9b02427 3. Botes, D T L F H V D W L. (2023, November 9). Aloe ferox leaf gel phytochemical content, antioxidant capacity, and possible health benefits.. https://pubs.acs.org/doi/10.1021/jf071110t 4. Chai, Y H., Yusup, S., Kadir, W N A., Wong, C Y., Rosli, S S., Ruslan, M S H., Chin, B L F., & Yiin, C L. (2020, December 29). Valorization of Tropical Biomass Waste by Supercritical Fluid Extraction Technology. Multidisciplinary Digital Publishing Institute, 13(1), 233-233. https://doi.org/10.3390/su13010233 5. Chatterjee, D., Bhattacharjee, P., Satpati, G G., & Pal, R. (2023, October 26). Spray Dried Extract of Phormidium valderianum as a Promising Source of Natural Antioxidant. http://downloads.hindawi.com/journals/ijfs/2014/897497.pdf 6. Chauhan, M A K J P Y S S S A A M A M. (2023, November 9). Novel carbopol-based transfersomal gel of 5-fluorouracil for skin cancer treatment: In Vitro characterization and in vivo study. https://www.tandfonline.com/doi/full/10.3109/10717544.2014.902146 7. Chellampillai, B., Pawar, A P., Dama, G Y., Joshi, P P., & Shaikh, K S. (2023, November 9). Novel solvent-free gelucire extract of Plumbago zeylanica using non-everted rat intestinal sac method for improved therapeutic efficacy of plumbagin.. https://www.sciencedirect.com/science/article/pii/S1056871912000706 8. Chen, Y., Huang, W., Chen, Y., Wu, M., Jia, R., & You, L. (2022, October 15). Influence of Molecular Weight of Polysaccharides from Laminaria japonica to LJP-Based Hydrogels: Anti-Inflammatory Activity in the Wound Healing Process. Multidisciplinary Digital Publishing Institute, 27(20), 6915-6915. https://doi.org/10.3390/molecules27206915 9. D'Avila, A A M L S J N. (2023, October 26). Selective and cost-effective protocol to separate bioactive triterpene acids from plant matrices using alkalinized ethanol: Application to leaves of Myrtaceae species. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522832/pdf/ 10. Dinç, E., Üçer, A., & Ünal, N. (2023, June 15). Three-dimensional strategies in the quantitative resolution of kinetic UV absorbance measurements for monitoring the oxidation of quercetin by oxidant agents and analyzing dietary supplement product. Elsevier BV, 31(2), 326-337. https://doi.org/10.38212/2224-6614.3455 11. Gertz, C., & Fiebig, H. (2023, November 9). Pyropheophytin a – Determination of thermal degradation products of chlorophyll a in virgin olive oil. https://onlinelibrary.wiley.com/doi/10.1002/ejlt.200600164 12. Gianfilippo.palmieri@unicam.it, G B U O C V S A 1 6 C I M C U O C V S A 1 6 C I M M U O C V S A 1 6 C I G F P U O C V S A 1 6 C I. (2023, November 9). Rheological, adhesive and release characterisation of semisolid Carbopol/tetraglycol systems.. https://www.sciencedirect.com/science/article/pii/S0378517305006538 13. Greuber, E., Vought, K., Patel, K., Suzuki, H., Usuda, K., Shiramizu, A., Koplowitz, L P., Koplowitz, B., Maïbach, H I., & Lissin, D. (2021, August 1). Biorelevant In Vitro Skin Permeation Testing and In Vivo Pharmacokinetic Characterization of Lidocaine from a Nonaqueous Drug-in-Matrix Topical System. Springer Science+Business Media, 22(6). https://doi.org/10.1208/s12249-021-02101-y 14. Gupta, N., Kulkarni, G T., Kumar, P., & Awasthi, R. (2020, March 3). Grewia asiatica Mucilage: A Smart Gelling Polymeric Material for Pharmaceutical Applications In Vitro Studies. , 12(2), 117-126. https://doi.org/10.2174/2666145412666191125124644 15. Gyanchandani, N D., Yamamoto, M., Nigams, I C., & Hughes, D W. (2023, November 9). Anthraquinone drugs. I. Thin-layer chromatographic identification of aloes, cascara, senna, and certain synthetic laxatives in pharmaceutical dosage forms.. https://jpharmsci.org/retrieve/pii/S002235491536740X 16. Hosni, S., Gani, S S A., Orsat, V., Hassan, M., & Abdullah, S. (2023, January 4). Ultrasound-Assisted Extraction of Antioxidants from Melastoma malabathricum Linn.: Modeling and Optimization Using Box–Behnken Design. Multidisciplinary Digital Publishing Institute, 28(2), 487-487. https://doi.org/10.3390/molecules28020487 17. Khedr, A I., Goda, M S., Farrag, A F S., Nasr, A M., Swidan, S., Nafie, M S., Abdel‐Kader, M S., Badr, J M., & Abdelhameed, R F A. (2022, September 24). Silver Nanoparticles Formulation of Flower Head’s Polyphenols of Cynara scolymus L.: A Promising Candidate against Prostate (PC-3) Cancer Cell Line through Apoptosis Activation. Multidisciplinary Digital Publishing Institute, 27(19), 6304-6304. https://doi.org/10.3390/molecules27196304 18. Kurniawansyah, I S., Rusdiana, T., Sopyan, I., Arya, I F D., Wahab, H A., & Nurzanah, D. (2023, August 10). Comparative Study of In Situ Gel Formulation Based on the Physico-Chemical Aspect: Systematic Review. Multidisciplinary Digital Publishing Institute, 9(8), 645-645. https://doi.org/10.3390/gels9080645 19. Maache-Rezzoug, Z., Rezzoug, S A., & Allaf, K. (2023, November 9). DEVELOPMENT OF A NEW DRYING PROCESS – DEHYDRATION BY CYCLICAL PRESSURE DROPS (D.D.S.): APPLICATION TO THE COLLAGEN GEL. https://www.tandfonline.com/doi/abs/10.1081/DRT-120001369 20. Masoko, P., & Masiphephethu, M V. (2023, November 9). Phytochemical Investigation, Antioxidant and Antimycobacterial Activities of Schkuhria pinnata (Lam) Thell Extracts Against Mycobacterium smegmatis. https://journals.sagepub.com/doi/10.1177/2515690X19866104 21. Opanasopit_p@su.ac.th, P E S U 7 N P T E Y Y M T N S U 7 N P T N T R S U 7 N P T R P P S U 7 N P T P P A S U 7 N P T A P O S U 7 N P T. (2023, November 9). Optimization of Boesenbergia rotunda Extract-Loaded Polyvinyl Alcohol Hydrogel Wound Dressing by Box-Behnken Design. https://www.scientific.net/KEM.819.38 22. Renault, J., Voutquenne, L., Caron, C., Zeches‐hanrot, M., Berwanger, S., & Becker, H. (2023, November 9). Purification of Xanthohumol from Humulus lupulus by Centrifugal Partition Chromatography Using an Original Acetone Based Solvent Scale. https://www.tandfonline.com/doi/full/10.1080/10826070500509330 23. Rossell, Ś., Gonzalez, L E., & Hernandez, L. (2023, November 9). One-second time resolution brain microdialysis in fully awake rats. Protocol for the collection, separation and sorting of nanoliter dialysate volumes.. https://www.sciencedirect.com/science/article/pii/S1570023202008267 24. Sallustio, V., Farruggia, G., Cagno, M P D., Tzanova, M M., Marto, J., Ribeiro, H M., Gonçalves, L., Mandrone, M., Chiocchio, I., Cerchiara, T., Abruzzo, A., Bigucci, F., & Luppi, B. (2023, April 25). Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract. Multidisciplinary Digital Publishing Institute, 9(5), 362-362. https://doi.org/10.3390/gels9050362 25. Samant, S., Jagtap, V A., Kalangutkar, P., Morye, R., Gadekar, A., Rane, R., & Desai, S. (2023, January 1). Phytochemistry and therapeutic uses of Albizia lebbeck. , 11(5), 22-26. https://doi.org/10.22271/flora.2023.v11.i5a.884 26. Scott, W E., Ma, R M., Schaffer, P S., Fontainei, T D., Warmke, H E., Lebn, J., Costa., Garvin, J W., & Damico, J A. (2023, November 9). A survey of selected Solanaceae for alkaloids. https://www.sciencedirect.com/science/article/pii/S0095955315342529 27. Shankar, R., & Khare, P K. (2023, November 9). Pharmacognostic Studies on Hypodematium crenatum. https://www.tandfonline.com/doi/full/10.3109/13880209109082873 28. Silva, M D O M D., Filho, A C P D M., Sharma, P., Cruz, R M D., Souza, A D., Taques, A S., Silva, A P D., Castro, C F D S., & Ventura, M V A. (2023, May 9). Phytochemistry and biological activities of latex from Schubertia grandiflora Mart. (Apocynaceae). , 2(10), 47-54. https://doi.org/10.14295/bjs.v2i10.396 29. Sultana, S., Hossain, M L., AKTER, S., SHEIKH, S., & KARMAKAR, U K. (2023, January 1). Phytochemical Analysis and In Vitro Bioactivity Study of Methanol Extract of Byttneria pilosa (Family: Malvaceae). , 27(1)(27(1)), 173-183. https://doi.org/10.29228/jrp.301
Article Sidebar
Article Details
Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Transfer of Copyright and Permission to Reproduce Parts of Published Papers.
Authors retain the copyright for their published work. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.