DESIGN, SYNTHESIS AND ANTIBACTERIAL EVALUATION OF SOME NEW 2, 5-DISUBSTITUTED 1, 3, 4-OXADIAZOLE DERIVATIVES
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Keywords
In silico ADME, Molecular Docking, Synthesis, 1,3,4- Oxadiazole, Antimicrobial Activity.
Abstract
Compounds containing 1,3,4-Oxadiazole nucleus investigated for CYP51 inhibitory activity. Current research work describes the designing, molecular docking, synthesis and structural elucidation of certain new 2,5-disubstituted 1,3,4-Oxadiazole derivatives investigated for antimicrobial activity. Series of the 2,5-disubstituted 1,3,4-Oxadiazole derivatives were designed and show good in silico ADME properties. The molecular docking study was done by Autodock vina software exploring better interaction with target protein and could be the potent inhibitor of ergosterol biosynthesis. The novel 2,5-disubstituted 1,3,4-Oxadiazole derivatives synthesized by conventional heating method as well as microwave irradiation method. The microwave assisted synthesis remarkely higher yield at less time compared to conventional synthesis. Structural elucidation was done by FTIR, 1H NMR and Mass spectroscopy. The synthesized compounds subjected to in vitro antimicrobial activity by agar diffusion method and all compounds show good inhibition of bacterial growth.
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References
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